Effects of chronic nicotine administration and its withdrawal on striatal FosB/ΔFosB and c-Fos expression in rats and mice

@article{Marttila2006EffectsOC,
  title={Effects of chronic nicotine administration and its withdrawal on striatal FosB/$\Delta$FosB and c-Fos expression in rats and mice},
  author={Kristiina Marttila and Helena Raattamaa and Liisa Ahtee},
  journal={Neuropharmacology},
  year={2006},
  volume={51},
  pages={44-51}
}
DeltaFosB, a member of Fos family of transcription factors, is implicated in behavioural responses and synaptic plasticity induced by abused drugs. We studied the expressions of FosB/DeltaFosB and c-Fos immunohistochemically in two dopaminergic brain areas, nucleus accumbens (NAcc) and caudate-putamen (CPu). In mice neither 2- nor 7-week oral nicotine treatment induced expression of long-lived DeltaFosB isoforms although during the treatment in the NAcc FosB/DeltaFosB expression was increased… Expand
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