Effects of chronic neuroleptic treatment on agonist affinity states of the dopamine-D2 receptor in the rat brain.

@article{Hall1987EffectsOC,
  title={Effects of chronic neuroleptic treatment on agonist affinity states of the dopamine-D2 receptor in the rat brain.},
  author={H{\aa}kan Hall and Maria S{\"a}llemark},
  journal={Pharmacology & toxicology},
  year={1987},
  volume={60 5},
  pages={
          359-63
        }
}
The effects of repeated oral administration to rats of three antipsychotic compounds (haloperidol 1 mumol/kg, raclopride 5 mumol/kg and remoxipride 10 mumol/kg) on agonist affinity states of the dopamine-D2 receptor were studied using 3H-spiperone binding to rat striatal homogenates in vitro. The competition between 3H-spiperone and dopamine was analyzed using the iterative nonlinear computer program LIGAND. The treatment of rats with haloperidol, raclopride and remoxipride caused an increased… CONTINUE READING
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