Effects of chronic lead exposure on short-term and long-term depression in area CA1 of the rat hippocampus in vivo.

@article{Ruan2000EffectsOC,
  title={Effects of chronic lead exposure on short-term and long-term depression in area CA1 of the rat hippocampus in vivo.},
  author={Diyun Ruan and Kong Yan and Shaolin Ge and Yun-sheng Xu and Jacqueline Tien-Hsiang Chen and Mengyu Wang},
  journal={Chemosphere},
  year={2000},
  volume={41 1-2},
  pages={165-71}
}
Chronic developmental lead (Pb) exposure to the rat has been reported to impair the long-term potentiation (LTP) in area CA1 and DG of the hippocampus. The present study was performed to investigate the effects of chronic Pb exposure on homosynaptic short-term depression (STD) and long-term depression (LTD) of population spikes (PS) in area CA1 of the rat hippocampus in vivo. Neonatal Wistar rats were exposed to Pb from parturition to weaning via the milk of dams fed with 0.2% lead acetate… CONTINUE READING