Effects of chronic kidney disease and uremia on hepatic drug metabolism and transport

@inproceedings{Yeung2014EffectsOC,
  title={Effects of chronic kidney disease and uremia on hepatic drug metabolism and transport},
  author={Catherine K. Yeung and Danny D. Shen and Kenneth E. Thummel and Jonathan Himmelfarb},
  booktitle={Kidney international},
  year={2014}
}
The pharmacokinetics of non-renally cleared drugs in patients with chronic kidney disease is often unpredictable. Some of this variability may be due to alterations in the expression and activity of extra renal drug-metabolizing enzymes and transporters, primarily localized in the liver and intestine. Studies conducted in rodent models of renal failure have shown decreased mRNA and protein expression of many members of the cytochrome P450 enzyme (CYP) gene family and the ATP-binding cassette… CONTINUE READING