Effects of chronic infusion of neurotensin and a neurotensin NT1 selective analogue PD149163 on amphetamine-induced hyperlocomotion.

@article{Norman2008EffectsOC,
  title={Effects of chronic infusion of neurotensin and a neurotensin NT1 selective analogue PD149163 on amphetamine-induced hyperlocomotion.},
  author={Christine Norman and Simon Richard Graham Beckett and Clare H. Spicer and David P. C. Ashton and Xavier Langlois and Giffery W. Bennett},
  journal={Journal of psychopharmacology},
  year={2008},
  volume={22 3},
  pages={
          300-7
        }
}
Neurotensin (NT) has been proposed as an endogenous antipsychotic based in part on the similarity in behavioural effects to antipsychotic drugs, for example, attenuation of both amphetamine-induced hyperlocomotion (AH) and amphetamine disrupted pre-pulse inhibition in the rat. However, there is some evidence that repeated administration of NT or an analogue produces behavioural tolerance to such effects. The present experiments sought to confirm and extend these findings by testing the effects… CONTINUE READING
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