Effects of chronic infusion of angiotensin II on renin and blood pressure in the late-gestation fetal sheep.

Abstract

OBJECTIVES Our purpose was to determine whether chronic physiologic elevations in plasma angiotensin II levels decrease plasma renin concentration, alter the relationship between active renin and prorenin in fetal plasma and kidney, and depress the expression of renal renin messenger ribonucleic acid in the fetus. STUDY DESIGN Seventeen chronically… (More)

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