Effects of chronic growth hormone hypersecretion on intrinsic contractility, energetics, isomyosin pattern, and myosin adenosine triphosphatase activity of rat left ventricle.

@article{Timsit1990EffectsOC,
  title={Effects of chronic growth hormone hypersecretion on intrinsic contractility, energetics, isomyosin pattern, and myosin adenosine triphosphatase activity of rat left ventricle.},
  author={Jean François Timsit and Bruno Riou and J{\'e}r{\^o}me Bertherat and Claudine Wisnewsky and Naga-aki Kato and Andrea S. Weisberg and Jean Lubetzki and Yves Lecarpentier and Saul Winegrad and J. J. Mercadier},
  journal={The Journal of clinical investigation},
  year={1990},
  volume={86 2},
  pages={
          507-15
        }
}
We studied papillary muscle mechanics and energetics, myosin phenotype, and ATPase activities in left ventricles from rats bearing a growth hormone (GH)--secreting tumor. 18 wk after tumor induction, animals exhibited a dramatic increase in body weight (+101% vs. controls) but no change in the ventricular weight/body weight ratio. The maximum isometric force of papillary muscles normalized per cross-sectional area rose markedly (+42%, P less than 0.05 vs. controls), whereas the maximum unloaded… CONTINUE READING
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