Effects of chronic ethanol exposure on GABA receptors and GABAB receptor modulation of 3H-GABA release in the hippocampus.

@article{Peris1997EffectsOC,
  title={Effects of chronic ethanol exposure on GABA receptors and GABAB receptor modulation of 3H-GABA release in the hippocampus.},
  author={Joanna Peris and Baerbel Eppler and M Hu and Don W. Walker and Bruce E. Hunter and Kathleen E. Wage George Mason and Kevin J. Anderson},
  journal={Alcoholism, clinical and experimental research},
  year={1997},
  volume={21 6},
  pages={1047-52}
}
Chronic ethanol treatment (CET), sufficient for decreasing long-term potentiation (LTP) in rats, also enhances 3H-GABA release from hippocampal slices in these same animals. The mechanism for an increase in GABA release may involve changes in presynaptic receptors. Therefore, we characterized presynaptic autoreceptor modulation of 3H-GABA release in hippocampal slices from control and CET rats. The effects of a GABAB receptor agonist (baclofen) and antagonist [2-hydroxy (OH)-saclofen] were… CONTINUE READING

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