Effects of chronic benzodiazepine exposure on stress-induced neuroactive steroid levels.

Since the neuroactive steroid 3alpha,5alpha-tetrahydroprogesterone (3alpha,5alpha-THP) has pharmacologic actions similar to benzodiazepine agonists such as diazepam, the influences of chronic diazepam exposure on stress-induced brain levels of 3alpha, 5alpha-THP were examined. Groups of male, female, orchidectomized (ORCH), and ovariectomized (OVX) rats… (More)