Effects of chronic amphetamine treatment on the glutamate concentration in cerebrospinal fluid and brain: implications for a theory of schizophrenia.

@article{Kim1981EffectsOC,
  title={Effects of chronic amphetamine treatment on the glutamate concentration in cerebrospinal fluid and brain: implications for a theory of schizophrenia.},
  author={Jang Soo Kim and Hans Helmut Kornhuber and U. Brand and H. G. Menge},
  journal={Neuroscience letters},
  year={1981},
  volume={24 1},
  pages={93-6}
}
In rats, chronic (12 days) amphetamine administration (5 mg/kg, s.c.) resulted in more than 30% decrease of the glutamate content in the cerebrospinal fluid (CSF) and concomitant increase of glutamate levels in the frontal cortex, striatum and hippocampus. In contrast, chronic amphetamine had no effect on the GABA contents in these areas. The data are compatible with the interpretation that amphetamine induces an increase of dopaminergic function in these brain regions which results in an… CONTINUE READING

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