Effects of chronic alcohol consumption on the expression of different NR1 splice variants in the brain of AA and ANA lines of rats.

@article{Winkler1999EffectsOC,
  title={Effects of chronic alcohol consumption on the expression of different NR1 splice variants in the brain of AA and ANA lines of rats.},
  author={Anja Winkler and Beatrice Mahal and Kalervo Kiianmaa and Walter Zieglg{\"a}nsberger and Rainer Spanagel},
  journal={Brain research. Molecular brain research},
  year={1999},
  volume={72 2},
  pages={166-75}
}
Following chronic alcohol treatment alterations in N-methyl-D-aspartate receptor subunit 1 and 2 (NR1 and NR2), mRNA and protein levels have been reported. The NR1 gene undergoes alternative RNA splicing, resulting in eight splice variants, which were shown to differ in their sensitivity to alcohol. Here, we studied mRNA and protein levels of NR1 splice variants in alcohol-preferring (AA) and alcohol-nonpreferring (ANA) rat lines under basal conditions (alcohol-naive), and following chronic… CONTINUE READING

From This Paper

Topics from this paper.

Citations

Publications citing this paper.
Showing 1-10 of 17 extracted citations

Synaptic effects induced by alcohol.

Current topics in behavioral neurosciences • 2013
View 1 Excerpt

Dysfunctional gene splicing as a potential contributor to neuropsychiatric disorders.

American journal of medical genetics. Part B, Neuropsychiatric genetics : the official publication of the International Society of Psychiatric Genetics • 2011
View 2 Excerpts

Alcoholism and Alternative Splicing of Candidate Genes

International journal of environmental research and public health • 2010
View 1 Excerpt

Similar Papers

Loading similar papers…