Effects of chronic administration of melatonin on spatial learning ability and long-term potentiation in lead-exposed and control rats.

@article{Cao2009EffectsOC,
  title={Effects of chronic administration of melatonin on spatial learning ability and long-term potentiation in lead-exposed and control rats.},
  author={Xiu-jing Cao and Ming Wang and Wei-heng Chen and Da-Miao Zhu and Jia-Qi She and Di-yun Ruan},
  journal={Biomedical and environmental sciences : BES},
  year={2009},
  volume={22 1},
  pages={
          70-5
        }
}
OBJECTIVE To explore the changes in spatial learning performance and long-term potentiation (LTP) which is recognized as a component of the cellular basis of learning and memory in normal and lead-exposed rats after administration of melatonin (MT) for two months. METHODS Experiment was performed in adult male Wistar rats (12 controls, 12 exposed to melatonin treatment, 10 exposed to lead and 10 exposed to lead and melatonin treatment). The lead-exposed rats received 0.2% lead acetate… CONTINUE READING

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