Effects of cholinergic overstimulation on isoflurane potency and efficacy in cortical and spinal networks.

@article{Grasshoff2007EffectsOC,
  title={Effects of cholinergic overstimulation on isoflurane potency and efficacy in cortical and spinal networks.},
  author={Christian Grasshoff and Berthold Drexler and Bernd Antkowiak},
  journal={Toxicology},
  year={2007},
  volume={229 3},
  pages={206-13}
}
In scenarios of terrorist attacks with organophosphorus compounds it appears likely that medical aid is required by victims not only suffering from the intoxication but also from physical trauma. These subjects may have to undergo surgical interventions, raising the need for anaesthesia. This prompts the question of how anaesthetic agents work in intoxicated patients. Organophosphates block acetylcholinesterase activity, thereby inducing excessive cholinergic overstimulation in the central… CONTINUE READING