Effects of cholinergic denervation on seizure development and neurotrophin messenger RNA regulation in rapid hippocampal kindling.

@article{Ferencz1997EffectsOC,
  title={Effects of cholinergic denervation on seizure development and neurotrophin messenger RNA regulation in rapid hippocampal kindling.},
  author={I Ferencz and Merab Kokaia and Marcus Keep and Eskil Elm{\'e}r and Madis Metsis and Zaal Kokaia and Olle Lindvall},
  journal={Neuroscience},
  year={1997},
  volume={80 2},
  pages={389-99}
}
Intraventricular 192 IgG-saporin was used to induce a selective lesion of basal forebrain cholinergic neurons in rats. When subjected to 40 rapid hippocampal kindling stimulations with 5-min intervals, these animals exhibited increased number of generalized seizures and a higher mean seizure grade in response to the first five stimulations, and required fewer stimuli to develop focal behavioural seizures, as compared to non-lesioned rats. In contrast, both groups showed similarly enhanced… CONTINUE READING

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