• DOI:10.1016/0955-2863(90)90039-N
Corpus ID: 38281577

Effects of choline deficiency and methotrexate treatment upon rat liver.

@article{Pomfret1990EffectsOC,
  title={Effects of choline deficiency and methotrexate treatment upon rat liver.},
  author={E. Pomfret and K. A. daCosta and S. Zeisel},
  journal={The Journal of nutritional biochemistry},
  year={1990},
  volume={1 10},
  pages={
          533-41
        }
}

• E. Pomfret, K. A. daCosta, S. Zeisel
• Published 1990
• Biology, Medicine
• The Journal of nutritional biochemistry

Choline deficiency and treatment with methotrexate (MTX) both are associated with fatty infiltration of the liver. Choline, methionine, and folate metabolism are interrelated and converge at the regeneration of methionine from homocysteine. MTX perturbs folate metabolism, and it is possible that it also influences choline metabolism. We fed rats a choline deficient diet for 2 weeks and/or treated them with methotrexate (MTX; 0.1 mg/kg daily). Choline deficiency lowered hepatic concentrations of… Expand