Effects of choline deficiency and methotrexate treatment upon rat liver.

Abstract

Choline deficiency and treatment with methotrexate (MTX) both are associated with fatty infiltration of the liver. Choline, methionine, and folate metabolism are interrelated and converge at the regeneration of methionine from homocysteine. MTX perturbs folate metabolism, and it is possible that it also influences choline metabolism. We fed rats a choline… (More)

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Cite this paper

@article{Pomfret1990EffectsOC, title={Effects of choline deficiency and methotrexate treatment upon rat liver.}, author={Elizabeth Anne Pomfret and Kerry Ann daCosta and Steven H Zeisel}, journal={The Journal of nutritional biochemistry}, year={1990}, volume={1 10}, pages={533-41} }