Effects of choline and other nicotinic agonists on the tectum of juvenile and adult Xenopus frogs: a patch-clamp study.

@article{Titmus1999EffectsOC,
  title={Effects of choline and other nicotinic agonists on the tectum of juvenile and adult Xenopus frogs: a patch-clamp study.},
  author={Margaret J. Titmus and Hsin Jung Tsai and Ricardo Lima and Susan B Udin},
  journal={Neuroscience},
  year={1999},
  volume={91 2},
  pages={753-69}
}
We have used anatomical methods and whole-cell patch-clamp recording to assess the distribution of nicotinic receptors in the tectum of Xenopus frogs and to measure effects of nicotinic ligands (carbachol, cytisine and nicotine) on glutamatergic spontaneous miniature excitatory postsynaptic currents. Our results confirm that retinotectal axons account for the majority of nicotinic receptors in the tectum and that nicotinic agonists exert presynaptic effects that increase the rate of transmitter… CONTINUE READING

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