Effects of cholesterol depletion by cyclodextrin on the sphingolipid microdomains of the plasma membrane.

@article{Ilangumaran1998EffectsOC,
  title={Effects of cholesterol depletion by cyclodextrin on the sphingolipid microdomains of the plasma membrane.},
  author={Subburaj Ilangumaran and Daniel C. Hoessli},
  journal={The Biochemical journal},
  year={1998},
  volume={335 ( Pt 2)},
  pages={433-40}
}
Sphingolipid microdomains are thought to result from the organization of plasma membrane sphingolipids and cholesterol into a liquid ordered phase, wherein the glycosylphosphatidylinositol (GPI)-anchored proteins are enriched. These domains, resistant to extraction by cold Triton X-100, can be isolated as buoyant membrane complexes (detergent-resistant membranes) in isopycnic density gradients. Here the effects of methyl-beta-cyclodextrin (MBCD), a specific cholesterol-binding agent that… CONTINUE READING
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