Effects of chlorpromazine on ischemic rat kidney: a functional and ultrastructural study.

@article{Jayachandran1985EffectsOC,
  title={Effects of chlorpromazine on ischemic rat kidney: a functional and ultrastructural study.},
  author={Satish Jayachandran and M M Mooppan and S Y Chou and Hong Kim},
  journal={Urology},
  year={1985},
  volume={25 4},
  pages={386-90}
}
The effects of chlorpromazine, an agent with inhibitory effects of calcium influx, phospholipase activation, and Na-K-ATPase, on preserving renal function and proximal tubular ultrastructure were evaluated in renal ischemia. After right nephrectomy chlorpromazine (0.025 mg) or 1 ml of 0.9 per cent saline was selectively administered to the rat kidney immediately prior to a sixty-minute occlusion of the remaining renal artery. Pretreatment with chlorpromazine resulted in a significant… CONTINUE READING