Effects of chloroquine on viral infections: an old drug against today's diseases?

@article{Savarino2003EffectsOC,
  title={Effects of chloroquine on viral infections: an old drug against today's diseases?},
  author={Andrea Savarino and Johan R. Boelaert and Antonio Cassone and Giancarlo Majori and Roberto Cauda},
  journal={The Lancet. Infectious diseases},
  year={2003},
  volume={3 11},
  pages={722-7}
}
Chloroquine is a 9-aminoquinoline known since 1934. Apart from its well-known antimalarial effects, the drug has interesting biochemical properties that might be applied against some viral infections. Chloroquine exerts direct antiviral effects, inhibiting pH-dependent steps of the replication of several viruses including members of the flaviviruses, retroviruses, and coronaviruses. Its best-studied effects are those against HIV replication, which are being tested in clinical trials. Moreover… CONTINUE READING

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