Effects of chlorhexidine on proteolytic and glycosidic enzyme activities of dental plaque bacteria.

@article{Beighton1991EffectsOC,
  title={Effects of chlorhexidine on proteolytic and glycosidic enzyme activities of dental plaque bacteria.},
  author={David Beighton and Joanne Decker and Karen A. Homer},
  journal={Journal of clinical periodontology},
  year={1991},
  volume={18 2},
  pages={
          85-9
        }
}
Chlorhexidine was tested for its ability to inhibit a wide range of glycosidic and proteolytic enzyme activities produced by Treponema denticola, Porphyromonas gingivalis, Bacteroides intermedius, Actinobacillus actinomycemcomitans, Capnocytophaga sputigena, Capnocytophaga gingivalis, Capnocytophaga orchracea, Capnocytophaga sp., Actinomyces viscosus, Streptococcus mitior, Streptococcus mutans, Streptococcus sobrinus, Streptococcus mitis, Streptococcus anginosus, Streptococcus oralis and… 

Inhibition of peptidase and glycosidase activities of Porphyromonas gingivalis, Bacteroides intermedius and Treponema denticola by plant extracts.

The inhibition of these enzyme activities is likely to reduce the virulence of these periodontophathic bacteria and to reduced the rate of dental plaque formation.

Antimicrobial effects of essential oils in combination with chlorhexidine digluconate.

There may be a role for essential oils in the development of novel anticaries treatments and the amount of chlorhexidine required to achieve an equivalent growth inhibition against the biofilm cultures was reduced 4-10-fold in combination with cinnamon, manuka, L. morrisonii, thymol, and Listerine.

Synergistic Degradation of Transferrin by Mutans Streptococci in Association with other Dental Plaque Bacteria

Supragingival plaque bacteria elaborated a range of complementary glycosidase and peptidase activities which interact in the degradation of glycoproteins resulting in the observed synergistic effects.

Inhibition of proteolytic, serpinolytic, and progelatinase-b activation activities of periodontopathogens by doxycycline and the non-antimicrobial chemically modified tetracycline derivatives.

Data from this study suggest that Doxy and CMTs have the potential to inhibit the periodontopathogenic bacterial proteinases, which contribute to tissue destruction cascades during periodontitis directly and indirectly by triggering the host response.

Inhibition of Porphyromonas gingivalis proteinases (gingipains) by chlorhexidine: synergistic effect of Zn(II).

Chlorhexidine is an effective inhibitor of gingipains, and the inhibition of R-gingipains is enhanced by Zn(II).

Dual role of iodine, silver, chlorhexidine and octenidine as antimicrobial and antiprotease agents

In vitro and ex vivo results suggest that wound healing devices which contain iodine, silver, chlorhexidine, and octenidine may add value to the antibacterial effect and also aid in chronic wound healing.

Chlorhexidine Inhibits the Proteolytic Activity of Root and Coronal Carious Dentin in vitro

Part of the effect of chlorhexidine in controlling caries progression in humans may be due to a decrease in the proteolytic activity of carious coronal and root dentin.

Clinical implications of the growth-suppressive effects of chlorhexidine at low and high concentrations on human gingival fibroblasts and changes in morphology.

Effects of CHX on the growth, morphology and proliferation of HGFs are investigated using human gingival fibroblasts and it is concluded that CHX only at the concentration of 0.002% does not interfere with HGF growth, that is so critical to wound healing.
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References

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The interaction of chlorhexidine with carboxyl, sulfate, and phosphate groups was studied in vitro, including factors that might interfere with these interactions, and the properties of cetylpyridine in the same systems also were investigated for comparison.

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It is shown that FDA/EB staining provides a method for direct measurement of bacteria vitality in dental plaque and, as such, can be of great value for testing the efficacy of various antiplaque agents.

Chlorhexidine affects arginine metabolism as well as glycolysis in a strain of Streptococcus sanguis.

The arginine deiminase pathway, as well as glycolysis, is thus depressed by sub-inhibitory concentrations of CHX and it is suggested that this could have far-reaching effects on overall plaque metabolism.

Chlorhexidine digluconate–an agent for chemical plaque control and prevention of gingival inflammation

Chlorhexidine is the most effective and most thoroughly tested antiplaque and antigingivitis agent known today and, owing to its great substantivity, effective in preventing and controlling plaque formation, breaking up existing plaque, and inhibiting and reducing the development of gingvitis.

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The purpose of this study was to determine the susceptibility to chlorhexidine of a range of bacteria which may be isolated from subgingival plaque. In addition, the effect of chlorhexidine on the

The mechanism of action of chlorhexidine. A study of plaque growth on enamel inserts in vivo.

It is concluded that chlorhexidine achieves plaque inhibition as a result of an immediate bactericidal action during the time of application and a prolonged bacteriostatic action as a consequence of adsorption to the pellicle coated enamel surface.