Effects of chlorate on the sulfation process of Trypanosoma cruzi glycoconjugates. Implication of parasite sulfates in cellular invasion.

@article{Ferrero2014EffectsOC,
  title={Effects of chlorate on the sulfation process of Trypanosoma cruzi glycoconjugates. Implication of parasite sulfates in cellular invasion.},
  author={M. Montserrat Real Ferrero and Luciana L{\'i}a Soprano and Diana Maria Castillo Acosta and Gabriela Andrea Intriago Garc{\'i}a and M{\'o}nica In{\'e}s Esteva and Alicia S Couto and Vilma Gladys Duschak},
  journal={Acta tropica},
  year={2014},
  volume={137},
  pages={
          161-73
        }
}
Sulfation, a post-translational modification which plays a key role in various biological processes, is inhibited by competition with chlorate. In Trypanosoma cruzi, the agent of Chagas' disease, sulfated structures have been described as part of glycolipids and we have reported sulfated high-mannose type oligosaccharides in the C-T domain of the cruzipain (Cz) glycoprotein. However, sulfation pathways have not been described yet in this parasite. Herein, we studied the effect of chlorate… CONTINUE READING
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