Effects of chemotherapy and radiotherapy on spermatogenesis.

  title={Effects of chemotherapy and radiotherapy on spermatogenesis.},
  author={Marvin L. Meistrich},
  journal={European urology},
  volume={23 1},
  pages={136-41; discussion 142}
Radiation and chemotherapy reduce sperm count and cause infertility in males. In the mouse, rat, and human, the differentiating spermatogonia are the most sensitive to killing by cytotoxic agents, resulting in short-term azoospermia. Stem spermatogonia are also killed by some agents. In the mouse, sperm production gradually recovers from surviving stem cells without a lag period. In the rat, however, surviving stem cells may remain as A spermatogonia for long times without initiating… CONTINUE READING
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