Effects of chemically modified heparin on Chlamydia trachomatis serovar L2 infection of eukaryotic cells in culture.

@article{Yabushita2002EffectsOC,
  title={Effects of chemically modified heparin on Chlamydia trachomatis serovar L2 infection of eukaryotic cells in culture.},
  author={Hiromitsu Yabushita and Yasuyuki Noguchi and Hiroko Habuchi and Satoko Ashikari and Ken Nakabe and Masaru Fujita and Masayoshi Noguchi and Jeffrey D Esko and Koji Kimata},
  journal={Glycobiology},
  year={2002},
  volume={12 5},
  pages={345-51}
}
The mechanism and inhibitors of Chlamydia trachomatis serovar L2 infection of eukaryotic host cells were studied using a tissue culture model infection system. Potent inhibition of infectivity was observed when elementary bodies (EBs) were exposed to heparin or when HeLa 229 cells were treated with heparinase. No significant inhibition was seen the other way around. The same potent inhibition was observed when EBs were exposed to chemically 2-O-desulfated heparin (2-ODS heparin), which is… CONTINUE READING

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