Effects of charge on antibody tissue distribution and pharmacokinetics.

@article{Boswell2010EffectsOC,
  title={Effects of charge on antibody tissue distribution and pharmacokinetics.},
  author={C Andrew Boswell and Devin B Tesar and Kiran Mukhyala and Frank-Peter Theil and Paul J. Fielder and Leslie A Khawli},
  journal={Bioconjugate chemistry},
  year={2010},
  volume={21 12},
  pages={2153-63}
}
Antibody pharmacokinetics and pharmacodynamics are often governed by biological processes such as binding to antigens and other cognate receptors. Emphasis must also be placed, however, on fundamental physicochemical properties that define antibodies as complex macromolecules, including shape, size, hydrophobicity, and charge. Electrostatic interactions between anionic cell membranes and the predominantly positive surface charge of most antibodies can influence blood concentration and tissue… CONTINUE READING

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