Effects of changing liver blood flow by exercise and food on kinetics and dynamics of saruplase.

@article{Griensven1995EffectsOC,
  title={Effects of changing liver blood flow by exercise and food on kinetics and dynamics of saruplase.},
  author={J M van Griensven and Koos Burggraaf and Joachim Gerloff and Wolfgang A. Guenzler and Horst Beier and Ron Kroon and Linda G M Huisman and Rik Schoemaker and K Kluft and Adam F Cohen},
  journal={Clinical pharmacology and therapeutics},
  year={1995},
  volume={57 4},
  pages={381-9}
}
OBJECTIVE To investigate the influence of changes in liver blood flow on the pharmacokinetics and pharmacodynamics of single-chain unglycosylated urokinase-type plasminogen activator. METHODS This open, randomized, crossover trial was carried out in the clinical research unit. Infusions of 37.5 mg saruplase and 90 mg indocyanine green were administered… CONTINUE READING