Effects of changes in blood flow rate on cell death and cell proliferation in carotid arteries of immature rabbits.

@article{Cho1997EffectsOC,
  title={Effects of changes in blood flow rate on cell death and cell proliferation in carotid arteries of immature rabbits.},
  author={Angela Cho and Lesley Mitchell and Dirk Koopmans and B. Lowell Langille},
  journal={Circulation research},
  year={1997},
  volume={81 3},
  pages={328-37}
}
Spontaneous and experimental changes in arterial blood flow rates affect tissue accumulation in developing arteries. To examine whether cell proliferation and/or cell death are affected by alterations in blood flow, we ligated the left external carotid artery of 3-week-old rabbits, which reduces left common carotid blood flow by 71%. In control arteries and after 2 days of flow reduction, agarose gel electrophoresis of DNA extracted from all carotid arteries resolved multiple low molecular… CONTINUE READING