Effects of casoxin 4 on morphine inhibition of small animal intestinal contractility and gut transit in the mouse

BACKGROUND AND AIMS Chronic opioid analgesia has the debilitating side-effect of constipation in human patients. The major aims of this study were to: 1) characterize the opioid-specific antagonism of morphine-induced inhibition of electrically driven contraction of the small intestine of mice, rats, and guinea pigs; and 2) test if the oral delivery of… (More)