Effects of carvedilol and its analog BM-910228 on mitochondrial function and oxidative stress.

@article{Abreu2000EffectsOC,
  title={Effects of carvedilol and its analog BM-910228 on mitochondrial function and oxidative stress.},
  author={R. Matos Abreu and Dario Loureiro Santos and Ant{\'o}nio J. M. Moreno},
  journal={The Journal of pharmacology and experimental therapeutics},
  year={2000},
  volume={295 3},
  pages={
          1022-30
        }
}
The antioxidant effects of carvedilol and its analog BM-910228 (also known as SB 211475) were studied in rat liver mitochondria as well as their action on mitochondrial bioenergetics. Carvedilol and BM-910228 inhibited ADP/Fe(2+)-initiated lipid peroxidation (measured in mitochondrial membranes as thiobarbituric acid reactive substances and oxygen consumption) with IC(50) values of 10.9 and 0. 33 microM, respectively. Under the same conditions, the IC(50) value for Trolox C was 18.8 microM. At… CONTINUE READING
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