Effects of carnosine on cyclophosphamide-induced hematopoietic suppression in mice.

@article{Xu2014EffectsOC,
  title={Effects of carnosine on cyclophosphamide-induced hematopoietic suppression in mice.},
  author={Meng Xu and Rong-Rong He and Yu-jia Zhai and Keiich Abe and Hiroshi Kurihara},
  journal={The American journal of Chinese medicine},
  year={2014},
  volume={42 1},
  pages={
          131-42
        }
}
Cyclophosphamide is one of the most widely used chemotherapeutic agents in treating cancers. Chemotherapy drug-induced oxidative stress produces side effects. The severity of myelosuppression increases with a high dose of cyclophosphamide. Chicken soup or chicken essence, a traditional Chinese aliment, is a popular health supplement for patients with cancers or other diseases in Asia. As a major functional component of chicken meat extract, carnosine (beta-alanyl-L-histidine), a dipeptide of… 

Figures from this paper

Therapeutic effects of Sheng Xue Fang in a cyclophosphamide-induced anaemia mouse model

SXF has good clinical application potential, however, the mechanism requires in-depth research, and is of great significance in anaemia treatment and provide a new perspective for Chinese medicine research.

Synergistic effect of Aminoguanidine and L-Carnosine against Thioacetamide-induced Hepatic Encephalopathy in rats: Behavioral, Biochemical and Ultra Structural Evidences.

It is depicted that combining AG with CAR exerted new intervention for hepatic and brain damage in HE due to their complementary antioxidant, anti-inflammatory effect and hypoammonemic effects via Nrf2/HO-1 activation and NO inhibition.

Metabolomic strategies and biochemical analysis of the effect of processed Rehmanniae radix extract on a blood-deficient rat model

The strategies of integrated metabolomic and biochemical analyses were combined to reveal the biological function and effective mechanism of PRR, which significantly increased the blood routine index levels and reversed the levels of SOD, GSH, and ATP.

Significant Effect of Acupressure in Elevating Blood Stem Cell Factor During Chemotherapy in Patients With Gynecologic Cancer.

The findings support that acupressure on specific acupoints increases blood SCF levels significantly, which may help protect chemotherapy patients from experiencing reduced hemoglobin levels and may relieve chemotherapy-induced myelosuppression in patients with gynecologic cancer.

Dipeptide Extract Modulates the Oxi-Antioxidant Response to Intense Physical Exercise

High pre-exercise dipeptide intake enhances antioxidant status and thus reduces the oxi-inflammatory response to intense exercise, and seems to have favourable potential for modulating oxidative stress and inflammation in physically active individuals following a strenuous exercise schedule.

Standardized Extract of Mangifera Indica L. Leaves as an Antimycobacterial and Immunomodulatory Agent

The promising results not only support the traditional claim of MIL as antibacterial and immunomodulatory agent but also provide data on their use in food supplements for immuno-pharmacological use.

References

SHOWING 1-10 OF 27 REFERENCES

Chemoprotective effects of carnosine against genotoxicity induced by cyclophosphamide in mice bone marrow cells

It appeared that carnosine with protective activity reduced the oxidative stress and genotoxicity induced by cyclophosphamide in bone marrow cells of mice.

Carnosine may reduce lung injury caused by radiation therapy.

Anti-Stress Effects of Carnosine on Restraint-Evoked Immunocompromise in Mice through Spleen Lymphocyte Number Maintenance

It is suggested that the maintenance of spleen lymphocyte number by carnosine was related with the inhibition of lymphocytes apoptosis caused by glucocorticoids overflow and stimulating lymphocyte proliferation, thus prevented immunocompromise in restraint-stressed mice.

[The radiation modifying properties of carnosine].

The influence of carnosine (beta-alanyl-l-histidine) on the survival rate of albino mice subjected to whole-body X-irradiation has been investigated and produced an insignificant protective effect and caused inhibition of the postirradiated histamine accumulation in the spleen.

Carnosine and its possible roles in nutrition and health.

  • A. Hipkiss
  • Biology
    Advances in food and nutrition research
  • 2009

Carnosine, homocarnosine and anserine: could they act as antioxidants in vivo?

It is concluded that, because of the high concentrations present in vivo, carnosine and anserine could conceivably act as physiological antioxidants by scavenging .OH, but that they do not have a broad spectrum of antioxidant activity, and their ability to inhibit lipid peroxidation is not well established.

Safety and Efficacy Evaluation of Carnosine, an Endogenous Neuroprotective Agent for Ischemic Stroke

The data suggest that this endogenous pleiotropic dipeptide is a strong candidate for further development as a stroke treatment, and Mechanistic data show that it influences multiple deleterious processes.

Effect of Curculigo orchioides on reflux esophagitis by suppressing proinflammatory cytokines.

Results suggest that anti-inflammatory and protective effects of ECR could attenuate the severity of reflux esophagitis and prevent esophageal mucosal damage.

Identification of Factors Involved in the Anti-Tumor Activity of Carnosine on Glioblastomas Using a Proteomics Approach

Human glioblastoma multiforme is the most malignant brain tumor in adults and is difficult to treat. Recently, it was demonstrated that the dipeptide carnosine inhibits tumor growth, but the main