Effects of carbohydrate-restricted diets on low-density lipoprotein cholesterol levels in overweight and obese adults: a systematic review and meta-analysis

@article{GjuladinHellon2019EffectsOC,
  title={Effects of carbohydrate-restricted diets on low-density lipoprotein cholesterol levels in overweight and obese adults: a systematic review and meta-analysis},
  author={Teuta Gjuladin-Hellon and Ian Glynn Davies and Peter E. Penson and Raziyeh Amiri Baghbadorani},
  journal={Nutrition Reviews},
  year={2019},
  volume={77},
  pages={161–180}
}
Context Carbohydrate-restricted diets may increase low-density lipoprotein cholesterol and thereby cardiovascular risk. Objective A systematic review and meta-analyses were conducted to compare the effects of very low, low, and moderate carbohydrate, higher fat diets versus high-carbohydrate, low-fat diets on low-density lipoprotein cholesterol and other lipid markers in overweight/obese adults. Data Sources Medline, PubMed, Cochrane Central, and CINAHL Plus were searched to identify large… 

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References

SHOWING 1-10 OF 196 REFERENCES

Effects of low-carbohydrate diets versus low-fat diets on metabolic risk factors: a meta-analysis of randomized controlled clinical trials.

TLDR
It is suggested that low-carbohydrate diets are at least as effective as low-fat diets at reducing weight and improving metabolic risk factors and could be recommended to obese persons with abnormal metabolicrisk factors for the purpose of weight loss.

Effects of low-carbohydrate diets v. low-fat diets on body weight and cardiovascular risk factors: a meta-analysis of randomised controlled trials

TLDR
A meta-analysis of randomised controlled trials assessing the effects of LC diets v. low-fat (LF) diets demonstrates opposite change in two important cardiovascular risk factors on LC diets – greater weight loss and increased LDL-cholesterol.

Effects of low-fat compared with high-fat diet on cardiometabolic indicators in people with overweight and obesity without overt metabolic disturbance: a systematic review and meta-analysis of randomised controlled trials.

TLDR
Dietary fat manipulation has a significant influence on blood lipid levels in people with overweight or obesity without metabolic disturbance in the present study.

Effects of low-carbohydrate and low-fat diets: a randomized trial.

TLDR
The low-carbohydrate diet was more effective for weight loss and cardiovascular risk factor reduction than the low-fat diet and Restricting carbohydrate may be an option for persons seeking to lose weight and reduce cardiovascular risk factors.

The Effects of Low-Carbohydrate versus Conventional Weight Loss Diets in Severely Obese Adults: One-Year Follow-up of a Randomized Trial

TLDR
The findings 1 year after randomization to a low-carbohydrate diet versus a high-fat weight loss diet (conventional diet) in severely obese adults with a high prevalence of diabetes or the metabolic syndrome are reported.

The Effects of a Low-Carbohydrate Diet vs. a Low-Fat Diet on Novel Cardiovascular Risk Factors: A Randomized Controlled Trial

TLDR
A low-carbohydrate diet resulted in similar or greater improvement in inflammation, adipocyte dysfunction, and endothelial dysfunction than a standard low-fat diet among obese persons, despite the differences in weight changes on diets.

Low Carbohydrate versus Isoenergetic Balanced Diets for Reducing Weight and Cardiovascular Risk: A Systematic Review and Meta-Analysis

TLDR
There is probably little or no difference in weight loss and changes in cardiovascular risk factors up to two years of follow-up when overweight and obese adults, with or without type 2 diabetes, are randomised to low CHO diets and isoenergetic balanced weight loss diets.

Very-low-carbohydrate ketogenic diet v. low-fat diet for long-term weight loss: a meta-analysis of randomised controlled trials.

TLDR
Individuals assigned to a VLCKD achieve a greater weight loss than those assigned to an conventional low-fat diet in the longterm; hence, a V LCKD may be an alternative tool against obesity.
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