Effects of captopril on cardiac and renal damage, and metabolic alterations in the nitric oxide-deficient hypertensive rat.

@article{Khattab2005EffectsOC,
  title={Effects of captopril on cardiac and renal damage, and metabolic alterations in the nitric oxide-deficient hypertensive rat.},
  author={Mahmoud Mohamed Khattab and Adel M. Mostafa and Othman Abdualla Al-Shabanah},
  journal={Kidney & blood pressure research},
  year={2005},
  volume={28 4},
  pages={243-50}
}
Chronic inhibition of nitric oxide (NO) synthesis is characterized by increased blood pressure accompanied with both cardiac hypertrophy as well as renal damage. We investigated whether the angiotensin-converting enzyme (ACE) inhibitor captopril can inhibit the cardiac hypertrophy and reverse the renal failure. We tested the influence of captopril on the nitrate-nitrite (NO(x)) in plasma and heart and kidney tissues. Oxidative stress, in terms of glutathione and thiobarbituric acid-reactive… CONTINUE READING