Effects of capsaicin on visceral smooth muscle: a valuable tool for sensory neurotransmitter identification.

  title={Effects of capsaicin on visceral smooth muscle: a valuable tool for sensory neurotransmitter identification.},
  author={L{\'o}r{\'a}nd Barth{\'o} and Rita Benkő and Riccardo Patacchini and G{\'a}bor Peth{\"o} and Ulrike Holzer‐Petsche and Peter Holzer and Zs{\'o}fia L{\'a}z{\'a}r and Sarolta Undi and L{\'a}szl{\'o} Ill{\'e}nyi and Andras Antal and {\~O}rs P{\'e}ter Horv{\'a}th},
  journal={European journal of pharmacology},
  volume={500 1-3},

Unravelling the Mystery of Capsaicin: A Tool to Understand and Treat Pain

The rationale of this review is to bring together and discuss the different types of studies that exploit capsaicin actions to shed light upon Capsaicin working both as a tool to understand pain but also as a treatment for chronic pain.

Role of extrinsic afferent neurons in gastrointestinal motility.

It is proposed that NO may be a sensory neurotransmitter, which plays a role in sympathetic reflexes, such as the inhibition of GI motility after laparotomy or by peritoneal irritation in animals with functionally inhibited capsaicin-sensitive nerves.

Facilitation and inhibition by capsaicin of cholinergic neurotransmission in the guinea-pig small intestine

Capsaicin has a dual effect on cholinergic neurotransmission and the facilitatory effect is indirect and involves tachykinin release and excitation of NK1 and NK3 receptors on cholinergic neurons.

High-Concentration Piperine: Capsaicin-Sensitive and -Insensitive Effects on Isolated Organs

The current isolated organ study in the guinea-pig ileum, urinary bladder and trachea confirms the presence of such components of effect and indicates TRPV1 involvement in the effect of 5 or 30 µmol/l of P on the basis of an inhibitory action of the antagonist BCTC.

Capsaicin, Nociception and Pain

The chemical and pharmacological properties of capsaicin and its derivatives in relation to their analgesic properties are described and the use of Capsaicin as an agonist of TRPV1 to model acute inflammation in slices and other ex vivo preparations is discussed.

Functional study on TRPV1‐mediated signalling in the mouse small intestine: involvement of tachykinin receptors

  • J. D. De ManS. Boeckx P. Pelckmans
  • Biology, Chemistry
    Neurogastroenterology and motility : the official journal of the European Gastrointestinal Motility Society
  • 2008
Activation of TRPV1 in the mouse intestine induces a contraction that is mediated by tachykinins most likely released from afferent nerves, which does not involve activation of intrinsic enteric motor nerves.

Effects of Cinnamaldehyde on Smooth Muscle Preparations

It is suggested that CNA excites the muscles of the bladder via activation of capsaicin-sensitive nerves; in the ileum, it may interact with TRPA1 located on tissue elements that initiate both purinergic and cholinergic mechanisms.



Bronchodilatation by tachykinins and capsaicin in the mouse main bronchus

  • S. Manzini
  • Biology, Chemistry
    British journal of pharmacology
  • 1992
The mouse main bronchus appears to be a monoreceptorial tissue containing only NK1 receptors which subserve bronchodilator functions and the consequent relaxation is probably mediated by the generation of prostanoids.

The dual function of capsaicin-sensitive sensory nerves in the bladder and urethra.

  • C. Maggi
  • Biology, Medicine
    Ciba Foundation symposium
  • 1990
The use of capsaicin, the pungent ingredient of red peppers, allowed us to investigate the anatomical and functional properties of a specific subset of sensory neurons in the lower urinary tract, which play a dual sensory and 'efferent' function.

Release of Calcitonin Gene—Related Peptide from Sensory Neurons a

CGRP released upon irritation of peripheral branches of primary afferents may evoke a variety of cardiovascular actions and influence motility in the gastrointestinal and urogenital tracts.

Effect of capsaicin on smooth muscles of rat vas deferens: involvement of calcitonin gene-related peptide?

The results suggest that capsaicin releases endogenous C GRP and that the released CGRP inhibits the contraction of the rat vas deferens by acting directly on smooth muscle cells but not on the sympathetic nerves.

Substance P and CGRP mediate motor response of rabbit colon to capsaicin.

Findings suggest that in the rabbit colon at least the following two neuropeptides are released from CAP-sensitive nerve fibers: a neurokinin peptide from nerve terminals located within the myenteric plexus and CGRP from terminals probably located inside the circular muscle layer.