Effects of capsaicin on the metabolism of rheumatoid arthritis synoviocytes in vitro.

  title={Effects of capsaicin on the metabolism of rheumatoid arthritis synoviocytes in vitro.},
  author={Marco Matucci-Cerinic and Simone Marabini and Susanne Jantsch and Mario Cagnoni and Gerald Partsch},
  journal={Annals of the Rheumatic Diseases},
  pages={598 - 602}
The effects of capsaicin, the ingredient of hot pepper, on rheumatoid arthritis synoviocytes have been studied. Capsaicin was shown to have a direct action on the metabolism of synovial cells. Thus at 10(-6) mol/l and at higher doses DNA synthesis was restored to the control level. Capsaicin at both doses induced an increase in the synthesis of collagenase and at the lower concentration (10(-8) mol/l) only of prostaglandins. These results indicate that the different effects of capsaicin on… 

Collagenase synthesis of rheumatoid arthritis synoviocytes: dose-dependent stimulation by substance P and capsaicin.

The experiments clearly show that in RA synoviocytes in vitro SP and capsaicin in low concentrations act as potent inducers of the synthesis and release of collagenase.

Immunosuppressive activity of capsaicinoids: capsiate derived from sweet peppers inhibits NF‐κB activation and is a potent antiinflammatory compound in vivo

Results suggest that CPT and related synthetic analogues target specific pathways involved in inflammation, and hold considerable potential for dietary health benefits as well as for pharmaceutical development.

Tachykinin receptor modulators: novel therapeutics for rheumatoid arthritis.

  • Brunelleschi
  • Biology, Medicine
    Expert opinion on investigational drugs
  • 1999
Different observations suggest that one approach to the treatment of RA might be to inhibit the local effects of neurokinins in the affected joints, and this review will summarise the more relevant aspects of this topic.

Potential of capsaicin-loaded transfersomes in arthritic rats

In vivo antiarthritic activity study shows that the prepared capsaicin-loaded transfersomal formulation possesses superior inhibitory activity than the marketed Thermagel formulation at the same dosage level, which could probably be due to the lesser permeability ofThermagel across the dermal barriers compared to the specially designed transfersomal delivery system.

Gingerol Reverses the Cancer-Promoting Effect of Capsaicin by Increased TRPV1 Level in a Urethane-Induced Lung Carcinogenic Model.

6-gingerol promoted TRPV1 level and drastically decreased the levels of EGFR, NF-κB, and cyclin D1 that favored reduced lung epithelial proliferation and EMT and reversed the cancer-promoting effect of capsaicin.

Rheumatoid Arthritis: Etiology and Naturopathic Treatments

It is important to view RA not only as a disease process that affects the joints, but as a systemic disorder that may include vasculitis, rheumatoid nodules in the pleural space, and blood-clott ing abnormal it ies.



Substance P activation of rheumatoid synoviocytes: neural pathway in pathogenesis of arthritis.

The specific stimulation of synoviocytes by the neuropeptide substance P represents a pathway by which the nervous system might be directly involved in the pathogenesis of rheumatoid arthritis.

Production of collagenase and prostaglandins by isolated adherent rheumatoid synovial cells.

Production of PGE2 and collagenase in large amounts in vitro by cells dispersed with proteolytic enzymes from rheumatoid arthritic synovectomy specimens suggests that they may be involved in joint destruction in vivo.


The view that certain drugs exert some of their pharmacological effects by stimulating prostaglandin synthetase is supported, as low concentrations of several emetic, purgative or irritant drugs in the absence of added co‐factors stimulated conversion of arachidonic acid to prostag landin E2 and F2α by prostaglandsin synthesis extracted from bull seminal vesicles.

Role of tachykinins in neurogenic inflammation.

Findings indicate that peptidergic nerve fibers are involved in the local regulation of blood flow, vascular permeability, and the tone of smooth muscles, and give new insights in the pathophysiology of hyperreactive disorders and neurogenic inflammation.

Autocrine control of collagenase synthesis by synovial fibroblasts

It is concluded that synovial fibroblasts regulate collagenase synthesis via an autocrine mechanism that includes the synthesis of both an inducer and inhibitor.

The influence of synovial fluids from patients with rheumatic diseases on chick embryo fibroblasts.

Primary chick-embryo fibroblasts (PCEF) appear to be a convenient and sensitive target cell system to study alterations of biochemical processes caused by crude synovial fluids and also of different origin by individual factors isolated from synovIAL fluids.

Capsaicin-induced ion fluxes in dorsal root ganglion cells in culture

A quantitative study of capsaicin- induced fluxes of sodium, guanidine, calcium, rubidium, and chloride ions in cultures of neonatal and adult rat DRG neurons, in conjunction with the use of a histochemical stain, provides indirect evidence that the sensitive cells correspond to the small, dark B-type neurons, which are negative for neurofilament immunoreactivity in vivo.

Evidence that substance P is a mediator of antidromic vasodilatation using somatostatin as a release inhibitor.

The results show that nerve-induced vasodilatation and release of SPLI are inhibited by somatostatin, consistent with the hypothesis that vasodolatation in the cat dental pulp produced by stimulation of the IAN is mediated by substance P.

Effect of neuropeptides on production of inflammatory cytokines by human monocytes.

The findings identify a potent mechanism for nervous system regulation of host defense responses in inflammation and immunity and since neuropeptides can be released from peripheral nerve endings into surrounding tissues.