Effects of capsaicin on the metabolism of rheumatoid arthritis synoviocytes in vitro.

@article{MatucciCerinic1990EffectsOC,
  title={Effects of capsaicin on the metabolism of rheumatoid arthritis synoviocytes in vitro.},
  author={Marco Matucci-Cerinic and Simone Marabini and Susanne Jantsch and Mario Cagnoni and Gerald Partsch},
  journal={Annals of the Rheumatic Diseases},
  year={1990},
  volume={49},
  pages={598 - 602}
}
The effects of capsaicin, the ingredient of hot pepper, on rheumatoid arthritis synoviocytes have been studied. Capsaicin was shown to have a direct action on the metabolism of synovial cells. Thus at 10(-6) mol/l and at higher doses DNA synthesis was restored to the control level. Capsaicin at both doses induced an increase in the synthesis of collagenase and at the lower concentration (10(-8) mol/l) only of prostaglandins. These results indicate that the different effects of capsaicin on… 

Collagenase synthesis of rheumatoid arthritis synoviocytes: dose-dependent stimulation by substance P and capsaicin.

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    Expert opinion on investigational drugs
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Different observations suggest that one approach to the treatment of RA might be to inhibit the local effects of neurokinins in the affected joints, and this review will summarise the more relevant aspects of this topic.

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