Effects of capsaicin on pharmacokinetics of pitavastatin in rats

@article{Chen2015EffectsOC,
  title={Effects of capsaicin on pharmacokinetics of pitavastatin in rats},
  author={Fen Chen and Xue-jia Zhai and Chao-ran Zhu and Yong-ning Lu},
  journal={Xenobiotica},
  year={2015},
  volume={45},
  pages={171 - 176}
}
Abstract 1. Capsaicin (CAP) is the primary pungent principle in peppers and an inhibitor of CYP3A subfamily and P-gp. 2. Pitavastatin is mainly metabolized via glucuronidation and metabolism by hepatic CYPs is minimal. Pitavastatin is taken up by Oatp1b2 (encoded by Slco1b2) in rat. 3. The pharmacokinetics results showed that AUC and Cmax in the group pre-treated with 3 mg/kg/d CAP were increased by 1.2 fold and 1.6 fold; AUC and Cmax in the group pre-treated with 8 mg/kg/d CAP were increased… Expand
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