Effects of capsaicin on intestinal cephalexin absorption in rats.

  title={Effects of capsaicin on intestinal cephalexin absorption in rats.},
  author={Yukiko Komori and Tetsuya Aiba and Risa Sugiyama and Chie Nakai and Hiromu Kawasaki and Yuji Kurosaki},
  journal={Biological \& pharmaceutical bulletin},
  volume={30 3},
The effects of capsaicin on intestinal cephalexin absorption were investigated by means of in situ single pass perfusion in rats to clarify whether this pungent compound present in spice is a potential factor altering the intestinal drug absorption processes. Under the control condition, cephalexin was absorbed at a rate of 1.16+/-0.08 and 0.90+/-0.06 nmol/min/cm in the jejunum and ileum, respectively. The intestinal cephalexin absorption rate was decreased when capsaicin was dissolved in the… 

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