Effects of capsaicin on intestinal cephalexin absorption in rats.

@article{Komori2007EffectsOC,
  title={Effects of capsaicin on intestinal cephalexin absorption in rats.},
  author={Yukiko Komori and Tetsuya Aiba and Risa Sugiyama and Chie Nakai and Hiromu Kawasaki and Yuji Kurosaki},
  journal={Biological \& pharmaceutical bulletin},
  year={2007},
  volume={30 3},
  pages={
          547-51
        }
}
The effects of capsaicin on intestinal cephalexin absorption were investigated by means of in situ single pass perfusion in rats to clarify whether this pungent compound present in spice is a potential factor altering the intestinal drug absorption processes. Under the control condition, cephalexin was absorbed at a rate of 1.16+/-0.08 and 0.90+/-0.06 nmol/min/cm in the jejunum and ileum, respectively. The intestinal cephalexin absorption rate was decreased when capsaicin was dissolved in the… 

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References

SHOWING 1-10 OF 28 REFERENCES

Effect of capsaicin on gastric acid secretion and mucosal blood flow in the rat.

It is suggested that the effect of capsaicin on the acid secretion and mucosal blood flow is by the release of endogenous gastric secretagogues which increase both tissue perfusion and the secretory activity.

Vasoactive intestinal polypeptide: a transmitter in submucous neurons mediating secretion in guinea pig distal colon.

Evidence is provided that VIP is a neurotransmitter within the submucous plexus involved in regulation of epithelial transport in the guinea pig colon and that it displaced the binding of [125I]VIP to epithelial receptors.

Valacyclovir: a substrate for the intestinal and renal peptide transporters PEPT1 and PEPT2.

It is concluded that valacyclovir is a substrate for the peptide transporters PEPT1 and P EPT2 and that a peptide bond is not a prerequisite for recognition as a substrate by the peptides transporter.

The inhibitory modulation of guinea-pig intestinal peristalsis caused by capsaicin involves calcitonin gene-related peptide and nitric oxide

Capsaicin-sensitive afferent neurons do not participate in the neural pathways subserving peristalsis in the guinea-pig small intestine, but modulate peristaltic activity upon stimulation with capsaicin.

PEPT1-Mediated Cefixime Uptake into Human Intestinal Epithelial Cells Is Increased by Ca2+ Channel Blockers

It is shown that cefixime transport mediated by the intestinal H+-coupled peptide transporter PEPT1 leads to intracellular acidification, and changes in Ca2+in levels affect pH regulatory systems, such as apical Na+ and H+ exchange, and thereby alter the H+ gradient that serves as the driving force for uptake of β-lactams into intestinal epithelial cells.

Expression of vanilloid receptor-1 in epithelial cells of human antral gastric mucosa

VR1-immunoreactivity was evident in antral epithelial cells exhibiting characteristics of endocrine-like cells, which may indicate that the gastroprotective effects of capsaicin, which hitherto have been attributed to primary afferent neurons, at least partly may be explained by an action on specific epithelial Cells in the antrum.

Vasodilator effect of adrenomedullin and calcitonin gene-related peptide receptors in rat mesenteric vascular beds.

The results suggest that adrenomedullin induces nonadrenergic and noncholinergic vasodilation in which CGRP receptors may be involved.