Effects of capsaicin on central monoaminergic mechanisms in the rat

  title={Effects of capsaicin on central monoaminergic mechanisms in the rat},
  author={Mih{\'a}ly Haj{\'o}s and K. -G. Svensson and Hans Nissbrandt and Ferenc Ob{\'a}l and Arvid Carlsson},
  journal={Journal of Neural Transmission},
The acute and chronic effects of capsaicin (s.c.) on the monoamines in the preoptic region + hypothalamus (RPO-H), spinal cord, substantia nigra and striatum were studied. Levels of DOPA, DA, DOPAC, HVA, 3-MT, NA, Trp, 5-HTP, 5-HT and 5-HIAA were determined by means of liquid chromatography (HPLC-EC). In response to acute capsaicin treatment, the levels of DA, DOPAC and DA synthesis rate (DOPA formation) were increased in a dose-dependent manner in the RPO-H and spinal cord. The disappearance… CONTINUE READING


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Coexistence of substance P and calcitonin gene-related peptide-like immunoreactivities in sensory nerves in relation to cardiovascular and bronchoconstrictor effects of capsaicin

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