Effects of cannabinoids on nitric oxide production by chondrocytes and proteoglycan degradation in cartilage.

@article{Mbvundula2005EffectsOC,
  title={Effects of cannabinoids on nitric oxide production by chondrocytes and proteoglycan degradation in cartilage.},
  author={Estery C Mbvundula and Rowena A. D. Bunning and Kim Drummond Rainsford},
  journal={Biochemical pharmacology},
  year={2005},
  volume={69 4},
  pages={635-40}
}
Cannabinoids have been reported to have anti-inflammatory effects and reduce joint damage in animal models of arthritis. This suggests a potential therapeutic role in arthritis of this group of compounds. Cannabinoids were studied to determine whether they have direct effects on chondrocyte metabolism resulting in cartilage protection. Synthetic cannabinoids, R-(+)-Win-55,212 (Win-2) and S-(-)-Win-55,212 (Win-3) and the endocannabinoid, anandamide, were investigated on unstimulated or IL-1… CONTINUE READING
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