Effects of cannabinoid receptor antagonists on maintenance and reinstatement of methamphetamine self-administration in rhesus monkeys.

@article{Schindler2010EffectsOC,
  title={Effects of cannabinoid receptor antagonists on maintenance and reinstatement of methamphetamine self-administration in rhesus monkeys.},
  author={Charles W. Schindler and Leigh V. Panlilio and Joanne P. Gilman and Zuzana Justinova and V Kiran Vemuri and Alex Makriyannis and Steven R. Goldberg},
  journal={European journal of pharmacology},
  year={2010},
  volume={633 1-3},
  pages={44-9}
}
Cannabinoid receptor antagonists have shown some promise as treatments capable of reducing abuse and relapse to a number of abused drugs. In rodents, such effects have been observed with methamphetamine self-administration. However, the effects of cannabinoid receptor antagonists on methamphetamine self-administration and relapse have not been studied in primates. In the present study, rhesus monkeys were trained to respond on a three-component operant schedule. During the first 5-min component… CONTINUE READING

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