Effects of cannabinoid drugs on the deficit of prepulse inhibition of startle in an animal model of schizophrenia: the SHR strain

  title={Effects of cannabinoid drugs on the deficit of prepulse inhibition of startle in an animal model of schizophrenia: the SHR strain},
  author={R. Levin and F. F. Peres and V. Almeida and M. Calzavara and A. W. Zuardi and J. Hallak and J. Crippa and V. Ab{\'i}lio},
  journal={Frontiers in Pharmacology},
  • R. Levin, F. F. Peres, +5 authors V. Abílio
  • Published 2014
  • Medicine
  • Frontiers in Pharmacology
  • Clinical and neurobiological findings suggest that the cannabinoids and the endocannabinoid system may be implicated in the pathophysiology and treatment of schizophrenia. We described that the spontaneously hypertensive rats (SHR) strain presents a schizophrenia behavioral phenotype that is specifically attenuated by antipsychotic drugs, and potentiated by proschizophrenia manipulations. Based on these findings, we have suggested this strain as an animal model of schizophrenia. The aim of this… CONTINUE READING
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