Effects of cannabinoid and vanilloid drugs on positive and negative-like symptoms on an animal model of schizophrenia: The SHR strain

@article{Almeida2014EffectsOC,
  title={Effects of cannabinoid and vanilloid drugs on positive and negative-like symptoms on an animal model of schizophrenia: The SHR strain},
  author={V. Almeida and F. F. Peres and R. Levin and M. A. Suiama and V. Ab{\'i}lio},
  journal={Schizophrenia Research},
  year={2014},
  volume={153},
  pages={150-159}
}
  • V. Almeida, F. F. Peres, +2 authors V. Abílio
  • Published 2014
  • Medicine
  • Schizophrenia Research
  • Studies have suggested that the endocannabinoid system is implicated in the pathophysiology of schizophrenia. We have recently reported that Spontaneously Hypertensive Rats (SHRs) present a deficit in social interaction that is ameliorated by atypical antipsychotics. In addition, SHRs display hyperlocomotion - reverted by atypical and typical antipsychotics. These results suggest that this strain could be useful to study negative symptoms (modeled by a decrease in social interaction) and… CONTINUE READING
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