Effects of cannabidiol on behavioral seizures caused by convulsant drugs or current in mice.

@article{Consroe1982EffectsOC,
  title={Effects of cannabidiol on behavioral seizures caused by convulsant drugs or current in mice.},
  author={Paul F. Consroe and Marco Antonio Campana Benedito and Jos{\'e} Roberto de Souza de Almeida Leite and Elisaldo Luiz de Ara{\'u}jo Carlini and Raphael Mechoulam},
  journal={European journal of pharmacology},
  year={1982},
  volume={83 3-4},
  pages={293-8}
}
In mice, running, clonic and tonic convulsions and lethality were assessed following transcorneal (electroshock) current or convulsant drugs, each administered alone and after cannabidiol (CBD) pretreatment. CBD prevented tonic convulsions caused by a convulsant current (CC) 99.99, and by the convulsant dose (CD) 99.99 values of gamma-aminobutyric acid (GABA) inhibitors, 3-mercaptoproprionic acid (3MPA), picrotoxin (PIC), isonicotinic acid hydrazine (INH), pentylenetetrazol (PTZ) and… CONTINUE READING

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