Effects of canine distemper virus infection on lymphoid function in vitro and in vivo.

@article{Krakowka1975EffectsOC,
  title={Effects of canine distemper virus infection on lymphoid function in vitro and in vivo.},
  author={Steven G. Krakowka and Gary L Cockerell and Adalbert Koestner},
  journal={Infection and immunity},
  year={1975},
  volume={11 5},
  pages={1069-78}
}
In the present study, the immunodepressive effects of canine distemper virus (CDV) infection of dogs on two parameters of lymphocyte function, namely phytomitogen-induced cellular proliferation and skin allograft rejection, were investigated. Infection of susceptible gnotobiotic dogs with virulent R252-CDV resulted in a depression of peripheral blood lymphocyte mitogen response as measured by (3H)thymidine incorporation for up to 10 weeks after inoculation. This effect coincided with the… CONTINUE READING