Effects of candesartan on mortality and morbidity in patients with chronic heart failure: the CHARM-Overall programme.

@article{Pfeffer2003EffectsOC,
  title={Effects of candesartan on mortality and morbidity in patients with chronic heart failure: the CHARM-Overall programme.},
  author={Marc Pfeffer and Karl B Swedberg and Christopher B. Granger and Peter Held and John J V McMurray and Eric L. Michelson and Bertil Olofsson and Jan B Ostergren and Salim Yusuf and Stuart J. Pocock},
  journal={Lancet},
  year={2003},
  volume={362 9386},
  pages={759-66}
}
BACKGROUND Patients with chronic heart failure (CHF) are at high risk of cardiovascular death and recurrent hospital admissions. We aimed to find out whether the use of an angiotensin-receptor blocker could reduce mortality and morbidity. METHODS In parallel, randomised, double-blind, controlled, clinical trials we compared candesartan with placebo in three distinct populations. We studied patients with left-ventricular ejection fraction (LVEF) 40% or less who were not receiving angiotensin… CONTINUE READING
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