Effects of camptothecin analogues on DNA transformations mediated by calf thymus and human DNA topoisomerases I.

Abstract

Camptothecin (CPT) and 10 structural analogues were studied to characterize their effects on specific rearrangements of DNA structure mediated by human and calf thymus DNA topoisomerases I. A 30 base pair DNA duplex containing a single high-efficiency topoisomerase cleavage site was incubated with each of the enzymes in the presence of the inhibitors… (More)

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@article{Wang1998EffectsOC, title={Effects of camptothecin analogues on DNA transformations mediated by calf thymus and human DNA topoisomerases I.}, author={X Wang and Glenn F. Short and William D. Kingsbury and R. K. Johnson and Susanna Hecht}, journal={Chemical research in toxicology}, year={1998}, volume={11 11}, pages={1352-60} }