Effects of calsequestrin over-expression on excitation-contraction coupling in isolated rabbit cardiomyocytes.

@article{Miller2005EffectsOC,
  title={Effects of calsequestrin over-expression on excitation-contraction coupling in isolated rabbit cardiomyocytes.},
  author={Stewart L W Miller and Susan L. Currie and C. M. Loughrey and Sarah L Kettlewell and Tim Seidler and Deborah F Reynolds and Gerd Hasenfuss and Godfrey L. Smith},
  journal={Cardiovascular research},
  year={2005},
  volume={67 4},
  pages={667-77}
}
OBJECTIVE This study investigated the role of calsequestrin (CSQ) in the control of excitation-contraction (E-C) coupling in the heart. METHODS CSQ over-expression was induced in isolated rabbit ventricular cardiomyocytes using an adenovirus coding for rabbit CSQ (Ad-CSQ). After 24 h of culture, CSQ protein expression was increased by 58+/-18% (n=10). An adenovirus coding for beta-galactosidase (Ad-LacZ) was used as a control. RESULTS In voltage-clamped, Fura-2-loaded cardiomyocytes, L-type… CONTINUE READING

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Proceedings of the National Academy of Sciences of the United States of America • 2003
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