Effects of calphobindin II (annexin VI) on procoagulant and anticoagulant activities of cultured endothelial cells.

Abstract

Effects of human placental calphobindin II (CPB-II) on the protein C activation and prothrombin activation on the cell surface of cultured calf pulmonary arterial endothelial cells have been investigated. CPB-II inhibited thrombin generation by factor Xa bound to the surface of the cultured endothelial cells in a dose-dependent manner. The amount (IC50) of… (More)

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@article{Yoshizaki1992EffectsOC, title={Effects of calphobindin II (annexin VI) on procoagulant and anticoagulant activities of cultured endothelial cells.}, author={Hitomi Yoshizaki and Satoshi Tanabe and K. Arai and Akira Murakami and Yoshinao Wada and M Ohkuchi and Yoko Hashimoto and Masatoshi Maki}, journal={Chemical & pharmaceutical bulletin}, year={1992}, volume={40 7}, pages={1860-3} }