Effects of caloric restriction or augmentation in adult rats: longevity and lesion biomarkers of aging.

@article{Lipman1998EffectsOC,
  title={Effects of caloric restriction or augmentation in adult rats: longevity and lesion biomarkers of aging.},
  author={Ruth D. Lipman and Donald E Smith and Jeffrey B Blumberg and Roderick Terry Bronson},
  journal={Aging},
  year={1998},
  volume={10 6},
  pages={463-70}
}
Caloric restriction (CR) initiated in young rodents has been thoroughly documented to enhance longevity, but its efficacy when introduced at older ages has not been well investigated. Cohorts of 18- and 26-month-old male F344 x BN F1 hybrid rats were fed either: 1) NIH-31 meal (C); 2) vitamin and mineral fortified NIH-31 meal (R); or 3) vitamin and mineral fortified NIH-31 meal supplemented with corn oil and sweetened condensed milk (S). The C control rats were fed ad libitum, R rats were… CONTINUE READING

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