Effects of calcium on canine Purkinje fiber action potential duration in the presence of agents affecting potassium permeability.

@article{Siegal1980EffectsOC,
  title={Effects of calcium on canine Purkinje fiber action potential duration in the presence of agents affecting potassium permeability.},
  author={Mel Siegal and Brian F. Hoffman},
  journal={Circulation research},
  year={1980},
  volume={46 2},
  pages={
          227-36
        }
}
We used intracellular microelectrodes to study the effect of changes in extracellular calcium ion concentration [Ca]o on the transmembrane potentials of canine cardiac Purkinje fibers in control Tyrode's solution and in the presence of agents thought to modify membrane permeability to potassium. In Tyrode's solution, decreasing [Ca]o from 2.7 to 0.9 mM increased action potential duration measured at -60 mv (APD «,) and at full repolarization (APDioo) but did not significantly modify the normal… CONTINUE READING

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