Effects of calcium channel blockade in canine saphenous veins after storage at −190°C

@article{Ebeigbe1988EffectsOC,
  title={Effects of calcium channel blockade in canine saphenous veins after storage at −190°C},
  author={Anthony B. Ebeigbe and Else M{\"u}ller‐Schweinitzer and Arnold Vogel},
  journal={British Journal of Pharmacology},
  year={1988},
  volume={94}
}
1 Canine saphenous veins were investigated in vitro either within 24 h after removal or after storage at −190°C for 4–5 weeks in foetal calf serum containing 1.8 m dimethyl sulphoxide. 2 Contractions and 45Ca2+ uptake in response to both depolarization and guanfacine were studied in the absence and presence of the calcium channel antagonists diltiazem, verapamil, nifedipine and the two stereoisomers of a 1,4‐dihydropyridine derivative, namely the (+)−(S) enantiomer and the (−)−(R) enantiomer of… 
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References

SHOWING 1-10 OF 26 REFERENCES
Sources of calcium used during alpha 1‐ and alpha 2‐adrenergic contractions in canine saphenous veins.
TLDR
The present experiments indicate that in the dog's saphenous vein the mechanism underlying the influx of extracellular Ca2+ ions into the smooth muscle cells, to judge from the inhibiting effect of iproveratril, is most likely to be the same.
Functional studies on human veins after storage at − 190°C
TLDR
It is suggested that cryopreservation is a useful technique for storing human veins for pharmacological studies and that after thawing of frozen stored veins the contractile force development was unchanged, and the evidence suggested that the monoamine oxidase activity was unimpaired.
in vitro Effects of Calcium Antagonists PN 200-110, Nifedipine, and Nimodipine on Human and Canine Cerebral Arteries
  • E. Müller‐Schweinitzer, P. Neumann
  • Medicine, Chemistry
    Journal of cerebral blood flow and metabolism : official journal of the International Society of Cerebral Blood Flow and Metabolism
  • 1983
TLDR
The results suggest that due to its potent calcium-blocking activity on cerebral arteries, PN 200–110 might be of value for the prevention and treatment of cerebrovascular spasms following subarachnoid hemorrhage.
Stereoselectivity at the Calcium Channel: Opposite Action of the Enantiomers of a 1,4‐Dihydropyridine
TLDR
The stereoisomers of a dihydropyridine derivative may behave as a calcium entry blocker or a calciumEntry enhancer on vascular smooth muscle, depending only on the stereochemistry.
Role of extracellular calcium in contractions produced by activation of postsynaptic alpha-2 adrenoceptors in the canine saphenous vein.
TLDR
The results suggest that activation of postsynaptic alpha-2 adrenoceptors in CSV utilizes primarily extracellular Ca++ to produce contractions.
Nimodipine and inhibition of alpha adrenergic activation of the isolated canine saphenous vein.
TLDR
The findings support the concept that the efficacy of the agonist-receptor interaction or the efficiency of receptor-response coupling that determines the effect of calcium entry blockade on the adrenergic response is not determined by the subtype of alpha adrenoceptor.
Mechanisms of calcium antagonist-induced vasodilation.
TLDR
Only when the authors know how CAts interact with the processes that regulate Ca availability and sensitivity in smooth muscle can they understand why agents that "antagonize" the action of such a universal intracellular messenger can be effectively de­ ployed as selective therapeutic agents in cardiovascular medicine.
Characterization of postjunctional alpha-1 and alpha-2 adrenoceptors activated by exogenous or nerve-released norepinephrine in the canine saphenous vein.
TLDR
The results suggest that the alpha-1 and alpha-2 adrenoceptor-mediated concentration-effect curves to norepinephrine are almost coincident and that alpha- 2 adrenergic stimulation produces only partial activation of the vascular smooth muscle.
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